Ira tabas m d ph d
Ira Tabas, M.D., Ph.D., is an American molecular biologist who currently serves as Richard J. Stock Professor and Vice-Chair of Research in the Department of Medicine, Professor of Anatomy & Cell Biology at Columbia University in the City of New York, and an endocrinologist affiliated with NewYork–Presbyterian Hospital .
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Biography
Tabas attended Washington University in St. Louis, Missouri, where he received his medical degree and his doctorate in biochemistry. While completing an internship and residency in internal medicine and a fellowship in endocrinology and metabolism at Columbia University Medical Center in New York City, he also conducted a postdoctoral fellowship in Alan Tall laboratory in the Department of Medicine at Columbia University. He began his independent scientific career as a Columbia faculty in 1985, and currently serves as Vice-Chair of Research in the Department of Medicine
Cellular biology of advanced atherosclerotic plaque progression
A major research focus of Tabas is the molecular and cellular mechanisms and consequences resulting from macrophage apoptosis and from phagocytic clearance of apoptotic cells in advanced atherosclerotic lesions. One notable finding showed a critical link between the PERK / CHOP branch of the stress Unfolded protein response (UPR) and a calcium-induced apoptosis pathway, which involves an ER calcium-release channel IP3R, a calcium-sensitive protein kinase called CaMKII, and an oxidative stress-generating enzyme NADPH
Tabas developed nanoparticles that encapsulate and release an inflammation-resolving peptide drug. These nanomedicines can selectively home to tissue injury sites in mice, and release in a controlled manner over time.
Molecular mechanism linking insulin resistance to enhanced atherosclerosis
Tabas discovered a calcium-IP3R-CaMKII pathway plays a key role in glucagon-mediated excessive hepatic glucose production, insulin resistance, fatty liver, and dyslipidemia in the setting of obesity and type 2 diabetes.
Awards and honors
one of its members and has been awarded annually since 1980."