Girish Mahajan (Editor)

Interolog

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Interolog

An interolog is a conserved interaction between a pair of proteins which have interacting homologs in another organism. The term was introduced in a 2000 paper by Walhout et al.

Example

Suppose that A and B are two different interacting human proteins, and A' and B' are two different interacting dog proteins. Then the interaction between A and B is an interolog of the interaction between A' and B' if the following conditions all hold:

  • A is a homolog of A'. (Protein homologs have similar amino acid sequences and derive from a common ancestral sequence).
  • B is a homolog of B'.
  • A and B interact.
  • A' and B' interact.

    • Thus, interologs are homologous pairs of protein interactions across different organisms.

    References

    Interolog Wikipedia
    (Text) CC BY-SA