Species Human Entrez 3578 | Human Mouse Ensembl ENSG00000145839 | |
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Aliases IL9, HP40, IL-9, P40, interleukin 9 External IDs OMIM: 146931 MGI: 96563 HomoloGene: 492 GeneCards: IL9 | ||
Gene music using protein sequence of il9 interleukin 9
Interleukin 9, also known as IL-9, is a cytokine (cell signalling molecule) belonging to the group of interleukins.
Contents
Gene music using protein sequence of il9r interleukin 9 receptor
Function
Il-9 is a cytokine secreted by CD4+ helper cells that acts as a regulator of a variety of hematopoietic cells. This cytokine stimulates cell proliferation and prevents apoptosis. It functions through the interleukin-9 receptor (IL9R), which activates different signal transducer and activator (STAT) proteins and thus connects this cytokine to various biological processes. The gene encoding this cytokine has been identified as a candidate gene for asthma. Genetic studies on a mouse model of asthma demonstrated that this cytokine is a determining factor in the pathogenesis of bronchial hyperresponsiveness.
Interleukin-9 has also shown to inhibit melanoma growth in mice.