Insulysin

Insulysin (EC 3.4.24.56, insulinase, insulin-degrading enzyme, insulin protease, insulin proteinase, insulin-degrading neutral proteinase, insulin-specific protease, insulin-glucagon protease, metalloinsulinase, IDE) is an enzyme. This enzyme catalyses the following chemical reaction

Degradation of insulin, glucagon and other polypeptides. No action on proteins

This cytosolic enzyme is present in mammals and in many arthropods such as the fly Drosophila melanogaster.