The Innermost Circle of the All-highest were the most powerful members of the fictional race known as the Eddorians, the inhabitants of the planet Eddore, as described in the Lensman series of books written by E.E. Smith ("Doc" Smith).
The Eddorians are portrayed as a very ancient race, who have developed their mental powers to a very high degree, and whose sole motivation, both individually and as a race, is the acquisition of power. Having fought among themselves for untold millennia, they have finally arrived at a situation where no Eddorian is powerful enough to destroy any other. The dozen or so individuals who are marginally more powerful than their fellows become the Innermost Circle, and the most powerful of all becomes known as the All-highest.
In their battle with the forces of good, led by the inhabitants of the planet Arisia, a planet older than Eddore, the 'Innermost Circle' direct the activities of a large number of subjugated races until being finally destroyed by the massed might of the lensman and the Arisians, controlled by the Children of the Lens.