Routes ofadministration Oral Legal status Withdrawn Biological half-life 2.3 hours | ATC code M01AE10 (WHO) Metabolism Molar mass 281.306 g/mol | |
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Bioavailability High (rapid and complete absorption) | ||
Indoprofen is a non-steroidal anti-inflammatory drug. It was withdrawn worldwide in the 1980s after postmarketing reports of severe gastrointestinal bleeding.
A 2004 study using high-throughput screening found indoprofen to increase production of the survival of motor neuron protein, suggesting it may provide insight into treatments for spinal muscular atrophies.
Synthesis
The isoindolone ring system forms the nucleus for one of the more traditional "profen" NSAIDs.
Reduction of the nitro group in arylpropionic acid (1) gives the corresponding aniline (2). Reaction of the intermediate with the imide (3) from phthalic anhydride (ie. phthalimide) gives the product (4) in which the aniline nitrogen has exchanged with ammonia (apparently phthalic anhydride was not used directly). Treatment of the new imide with zinc in acetic acid leads, interestingly to reduction of but one of the carbonyl groups to afford indolone, indoprofen.