Amed was born and raised in Calgary, Alberta and is of Indian descent. Although not especially interested in fashion growing up, he did watch a fashion show on television hosted by Tim Blanks. Amed attended McGill University in Montreal, Quebec and after graduation worked as a management consultant. In 2000, he enrolled at Harvard Business School to complete an MBA. Upon graduation in 2002, he moved to London to work for McKinsey & Company, the global management consulting firm. He left McKinsey in 2006 to explore his interest in the fashion industry.
An industry outsider, Amed started writing a blog, "The Business of Fashion" about the fashion business in January 2007 from his sofa at home in London in the evenings, while consulting for fashion brands and emerging designers during the day. Prior to that, Amed had set up a company providing capital to designers, which lasted for a year. Soon, the blog attracted a global following of readers from around the world, and has since become a must-read for the global fashion industry. By 2013, The Business of Fashion blog had in his words "taken over my life". That year, Amed raised a seed round of funding and hired a team.
Amed has built a name for himself as an incisive interviewer. He has conducted interviews with some of the fashion world's biggest names including Karl Lagerfeld, Kate Moss, Giorgio Armani, Yohji Yamamoto, Raf Simons, Tom Ford, Tommy Hilfiger, Stella McCartney, Franca Sozzani, Natalie Massenet, Nick Knight, Dolce & Gabbana, and Jefferson Hack. He has also interviewed the CEOs of global fashion businesses including Kering, Chanel, Gucci, Bottega Veneta, Versace, Fendi, Yves Saint Laurent, Valentino, Calvin Klein, Nike, Benetton, Lacoste, and Marc Jacobs.
In 2011, Amed was named one of the 100 most influential men in Britain by British GQ and one of the 50 most influential Global Indians by Indian GQ.
In 2012, he was featured on the Wired 100 list of the most influential figures in Britain's digital economy and was ranked number one on Indian GQ's list of the 10 best-dressed Global Indians.
In 2015, he was named Honorary Professor of Fashion Business at the Glasgow Caledonian University.
In 2016, at the Council of Fashion Designers of America Awards, Amed was awarded the Media Award in Honor of Eugenia Sheppard.
In 2011, Amed launched a bag design collaboration with Bill Amberg, a renowned British leather goods designer. The bag, called The Calgary, received international media attention and promptly sold out.Pattern, Phaidon, 2013 (ISBN 0714849723; ISBN 978-0714849720)