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Thesis Structure and function of the cucumber malate synthase gene and expression during plant development (1989) Doctoral advisor Steven M. Smith
Chris J. Leaver Alma maters Queen's University Belfast, University of Edinburgh Academic advisors Steven M. Smith, Chris J. Leaver Institutions University of York, University of Glasgow, Stanford University | ||
Ian Alexander Graham FRS is a Professor of Biochemical Genetics in the Centre for Novel Agricultural Products (CNAP) at the University of York where he is also Head of the Department of Biology.
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Education
Graham was educated at Queen's University Belfast where he was awarded a Bachelor of Science degree in Botany and Genetics in 1986. He completed his PhD at the University of Edinburgh in 1989 on the structure and function of the malate synthase gene in cucumber supervised by Steven M. Smith and Chris J. Leaver.
Career
From 1990 to 1993 he was a postdoctoral researcher in the Department of Plant Sciences at the University of Oxford. He was appointed a Lecturer in the division of Biochemistry and Molecular Biology at University of Glasgow from 1994 to 1999. During 1994, he was a SERC/NATO funded research scientist in Department of Plant Biology at Stanford University. He has been Chair of Biochemical Genetics at York since 1999.
Research
Graham’s interests include how plants make and breakdown various metabolites, how these processes are controlled and how they impact on plant growth. He has used biochemical genetics to dissect the main metabolic pathways controlling oil mobilisation in Arabidopsis seed and provided new insight into how a lipid based signal controls seed germination. He has used similar approaches to investigate the synthesis of bioactive compounds in two of the world’s major medicinal plants. This has led to new understanding of how genome rearrangement has shaped the evolution of plant metabolism. The discovery of a 10 gene cluster responsible for the production of the anti-cancer compound noscapine in opium poppy provided the tools for molecular breeding of new commercial varieties. The discovery of a novel Cytochrome P450 – oxidoreductase gene fusion described the last unknown step in synthesis of morphine and codeine. Characterisation and genetic mapping of traits responsible for production of artemisinin in Artemisia annua has enabled development of F1 hybrid seed that can deliver a robust source of this vital antimalarial medication for the developing countries.
Awards and honours
Graham was elected a Fellow of the Royal Society (FRS) in 2016.