Iacono ([ˈjakono]) is a surname of Italian origin. Notable people with the surname include:
Alessandro Iacono (born 1973), former Italian professional footballerFranck Iacono (born 1966), French freestyle swimmerGianluca Iacono (born 1970), Italian voice actorMaurizio Iacono, member of the Canadian rock band KataklysmPaul Iacono (born 1988), American actorPaul Iacono (born 1954), American writer, producer, directorSal Iacono (born 1971), American comedian