Iacono ([ˈjakono]) is a surname of Italian origin. Notable people with the surname include:
Alessandro Iacono (born 1973), former Italian professional footballer
Franck Iacono (born 1966), French freestyle swimmer
Gianluca Iacono (born 1970), Italian voice actor
Maurizio Iacono, member of the Canadian rock band Kataklysm
Paul Iacono (born 1988), American actor
Paul Iacono (born 1954), American writer, producer, director
Sal Iacono (born 1971), American comedian