Species Human Entrez 3707 | Human Mouse Ensembl ENSG00000143772 | |
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Aliases ITPKB, IP3-3KB, IP3K, IP3K-B, IP3KB, PIG37, inositol-trisphosphate 3-kinase B External IDs MGI: 109235 HomoloGene: 1672 GeneCards: ITPKB | ||
Inositol-trisphosphate 3-kinase B is an enzyme that in humans is encoded by the ITPKB gene.
Function
The protein encoded by this gene regulates inositol phosphate metabolism by phosphorylation of second messenger inositol 1,4,5-trisphosphate to Ins(1,3,4,5)P4. The activity of this encoded protein is responsible for regulating the levels of a large number of inositol polyphosphates that are important in cellular signaling. Both calcium/calmodulin and protein phosphorylation mechanisms control its activity. Itpkb regulates immune cell function and is required for T and B cell development.
References
ITPKB Wikipedia(Text) CC BY-SA