Harman Patil (Editor)

ITK (gene)

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Species
  
Human

Entrez
  
3702

Human
  
Mouse

Ensembl
  
ENSG00000113263

ITK (gene)

Aliases
  
ITK, EMT, LPFS1, LYK, PSCTK2, IL2 inducible T-cell kinase

External IDs
  
OMIM: 186973 MGI: 96621 HomoloGene: 4051 GeneCards: ITK

Tyrosine-protein kinase ITK/TSK also known as interleukin-2-inducible T-cell kinase or simply ITK, is a protein that in humans is encoded by the ITK gene. ITK is a member of the TEC family of kinases and is highly expressed in T cells.

Contents

Function

This gene encodes an intracellular tyrosine kinase expressed in T-cells. The protein is thought to play a role in T-cell proliferation and differentiation. ITK is functionally important for the development and effector function of Th2 and Th17 cells.

Mice lacking ITK were shown to not be susceptible to asthma.

Structure

This protein contains the following domains, which are often found in intracellular kinases:

  • N-terminus – PH (pleckstrin homology domain)
  • TH – Tec family homology domain (including Bruton's tyrosine kinase Cys-rich motif and Proline rich region)
  • SH3 – (Src homology 3)
  • SH2 – (Src homology 2)
  • C-terminus – tyrosine kinase, catalytic domain

    • Interactions

    ITK (gene) has been shown to interact with:

    References

    ITK (gene) Wikipedia
    (Text) CC BY-SA