Species Human Entrez 3685 | Human Mouse Ensembl ENSG00000138448 | |
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Aliases ITGAV, CD51, MSK8, VNRA, VTNR, integrin subunit alpha V External IDs MGI: 96608 HomoloGene: 20510 GeneCards: ITGAV | ||
Integrin alpha-V is a protein that in humans is encoded by the ITGAV gene.
Contents
Function
ITAGV encodes integrin alpha chain V. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. Alpha V undergoes post-translational cleavage to yield disulfide-linked heavy and light chains, that combine with multiple integrin beta chains to form different integrins. Among the known associating beta chains (beta chains 1,3,5,6, and 8; 'ITGB1', 'ITGB3', 'ITGB5', 'ITGB6', and 'ITGB8'), each can interact with extracellular matrix ligands; the alpha V beta 3 integrin, perhaps the most studied of these, is referred to as the Vitronectin receptor (VNR). In addition to adhesion, many integrins are known to facilitate signal transduction.
Alpha V class integrins
In mammals the integrins that include alpha-V are :
As a drug target
The mAbs intetumumab, and abituzumab target this protein which is found on some tumour cells.