Species Human Entrez 3655 | Human Mouse Ensembl ENSG00000091409 | |
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Aliases ITGA6, CD49f, ITGA6B, VLA-6, integrin subunit alpha 6 External IDs MGI: 96605 HomoloGene: 20091 GeneCards: ITGA6 | ||
Integrin alpha-6 is a protein that in humans is encoded by the ITGA6 gene.
Contents
Function
The ITGA6 protein product is the integrin alpha chain alpha 6. Integrins are integral cell-surface proteins composed of an alpha chain and a beta chain. A given chain may combine with multiple partners resulting in different integrins. For example, alpha 6 may combine with beta 4 in the integrin referred to as TSP180, or with beta 1 in the integrin VLA-6. Integrins are known to participate in cell adhesion as well as cell-surface mediated signalling. Two transcript variants encoding different isoforms have been found for this gene.
Interactions
ITGA6 has been shown to interact with TSPAN4 and GIPC1.
References
ITGA6 Wikipedia(Text) CC BY-SA