Neha Patil (Editor)

IRGM

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Species
  
Entrez
  
345611

Human
  
Ensembl
  
ENSG00000237693

Aliases
  
IRGM, IFI1, IRGM1, LRG-47, LRG47, immunity-related GTPase M

External IDs
  
MGI: 1926262 HomoloGene: 78363 GeneCards: IRGM

Immunity-related GTPase family M protein (IRGM), also known as interferon-inducible protein 1 (IFI1), is an enzyme that in humans is IRGM gene.

IRGM is a member of the interferon-inducible GTPase family. The encoded protein may play a role in the innate immune response by regulating autophagy formation in response to intracellular pathogens.

Clinical relevance

Polymorphisms that affect the normal expression of this gene are associated with a susceptibility to Crohn's disease and tuberculosis.

References

IRGM Wikipedia


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