Species Human Entrez 345611 | Human Mouse Ensembl ENSG00000237693 | |
Aliases IRGM, IFI1, IRGM1, LRG-47, LRG47, immunity-related GTPase M External IDs MGI: 1926262 HomoloGene: 78363 GeneCards: IRGM | ||
Immunity-related GTPase family M protein (IRGM), also known as interferon-inducible protein 1 (IFI1), is an enzyme that in humans is IRGM gene.
IRGM is a member of the interferon-inducible GTPase family. The encoded protein may play a role in the innate immune response by regulating autophagy formation in response to intracellular pathogens.
Clinical relevance
Polymorphisms that affect the normal expression of this gene are associated with a susceptibility to Crohn's disease and tuberculosis.
References
IRGM Wikipedia(Text) CC BY-SA