Species Human Entrez 3663 | Human Mouse Ensembl ENSG00000128604 | |
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Aliases IRF5, SLEB10, interferon regulatory factor 5 External IDs MGI: 1350924 HomoloGene: 8088 GeneCards: IRF5 | ||
Gene music using protein sequence of irf5 interferon regulatory factor 5
Interferon regulatory factor 5 is a protein that in humans is encoded by the IRF5 gene.
Contents
Ancestral variation in sle genetics at irf5 and in the african american gwas john harley usa
Function
IRF5 is a member of the interferon regulatory factor (IRF) family, a group of transcription factors with diverse roles, including virus-mediated activation of interferon, and modulation of cell growth, differentiation, apoptosis, and immune system activity. Members of the IRF family are characterized by a conserved N-terminal DNA-binding domain containing tryptophan (W) repeats. Alternative splice variants encoding different isoforms exist.
Clinical significance
IRF5 acts as a molecular switch that controls whether macrophages will promote or inhibit inflammation. Blocking the production of IRF5 in macrophages may help treat a wide range of autoimmune diseases, and that boosting IRF5 levels might help treat people whose immune systems are weak, compromised, or damaged. IRF5 seems to work "either by interacting with DNA directly, or by interacting with other proteins that themselves control which genes are switched on."
