Entrez 3615 | Ensembl ENSG00000178035 | |
 | ||
Aliases IMPDH2, IMPD2, IMPDH-II, IMP (inosine 5'-monophosphate) dehydrogenase 2, inosine monophosphate dehydrogenase 2 External IDs MGI: 109367 HomoloGene: 48919 GeneCards: IMPDH2 | ||
Inosine-5'-monophosphate dehydrogenase 2, also known as IMP dehydrogenase 2, is an enzyme that in humans is encoded by the IMPDH2 gene.
Contents
Function
IMP dehydrogenase 2 is the rate-limiting enzyme in the de novo guanine nucleotide biosynthesis. It is thus involved in maintaining cellular guanine deoxy- and ribonucleotide pools needed for DNA and RNA synthesis. IMPDH2 catalyzes the NAD-dependent oxidation of inosine-5'-monophosphate into xanthine-5'-monophosphate, which is then converted into guanosine-5'-monophosphate.
Clinical significance
This gene is up-regulated in some neoplasms, suggesting it may play a role in malignant transformation.
References
IMPDH2 Wikipedia(Text) CC BY-SA