Entrez 3483 | Ensembl ENSG00000099769 | |
 | ||
External IDs MGI: 107973 HomoloGene: 37987 GeneCards: IGFALS | ||
Insulin-like growth factor binding protein, acid labile subunit, also known as IGFALS, is a protein which in humans is encoded by the IGFALS gene.
Contents
Function
The protein encoded by this gene is a serum protein that binds insulin-like growth factors, increasing their half-life and their vascular localization. Production of the encoded protein, which contains twenty leucine-rich repeats, is stimulated by growth hormone. Three transcript variants encoding two different isoforms have been found for this gene.
Clinical significance
Defects in this gene are a cause of acid-labile subunit deficiency, which manifests itself in a delayed and slow puberty.
Interactions
IGFALS has been shown to interact with IGFBP3.
References
IGFALS Wikipedia(Text) CC BY-SA