The International Statistical Classification of Diseases and Related Health Problems 10th Revision (ICD-10) is a coding of diseases and signs, symptoms, abnormal findings, complaints, social circumstances and external causes of injury or diseases, as classified by the World Health Organization (WHO). This page contains ICD-10 Chapter IV: Endocrine, nutritional and metabolic diseases.
This is an overview about the chapter IV (also called chapter E) of the International Statistical Classification of Diseases and Related Health Problems 10th Revision (ICD-10). This chapter is about Endocrine, nutritional and metabolic diseases.
The ICD-10 is a coding of diseases and signs, symptoms, abnormal findings, complaints, social circumstances and external causes of injury or diseases, as classified by the World Health Organization (WHO). The code set allows more than 155,000 different codes and permits tracking of many new diagnoses and procedures, a significant expansion on the 17,000 codes available in ICD-9.
(E00–E07) Thyroid gland / Thyroid hormone
(E00) Congenital iodine-deficiency syndrome
(E01) Iodine-deficiency-related thyroid disorders and allied conditions
(E01.0) Iodine-deficiency-related diffuse (endemic) goitre
(E01.1) Iodine-deficiency-related multinodular (endemic) goitre
(E01.2) Iodine-deficiency-related (endemic) goitre, unspecified
(E01.8) Other iodine-deficiency-related thyroid disorders and allied condition
(E02) Subclinical iodine-deficiency hypothyroidism
(E03) Other hypothyroidism
(E03.0) Congenital hypothyroidism with diffuse goitre
(E03.1) Congenital hypothyroidism without goitre
(E03.2) Hypothyroidism due to medicaments and other exogenous substances
(E03.3) Postinfectious hypothyroidism
(E03.4) Atrophy of thyroid (acquired)
(E03.5) Myxoedema coma
(E04) Other nontoxic goitre
(E05) Thyrotoxicosis (hyperthyroidism)
(E05.0) Thyrotoxicosis with diffuse goitre
Graves' disease
(E05.1) Thyrotoxicosis with toxic single thyroid nodule
(E05.2) Thyrotoxicosis with toxic multinodular goitre
(E05.3) Thyrotoxicosis from ectopic thyroid tissue
(E05.4) Thyrotoxicosis factitia
(E05.5) Thyroid crisis or storm
(E05.8) Other thyrotoxicosis
(E05.9) Thyrotoxicosis, unspecified
(E06) Thyroiditis
(E06.0) Acute thyroiditis
(E06.1) Subacute thyroiditis
De Quervain's thyroiditis
(E06.2) Chronic thyroiditis with transient thyrotoxicosis
(E06.3) Autoimmune thyroiditis
Hashimoto's thyroiditis
(E06.4) Drug-induced thyroiditis
(E06.5) Other chronic thyroiditis
Riedel's thyroiditis
(E06.9) Thyroiditis, unspecified
(E07) Other disorders of thyroid
(E07.0) Hypersecretion of calcitonin
(E07.1) Dyshormogenetic goitre
(E07.8) Other specified disorders of thyroid
Sick-euthyroid syndrome
(E07.9) Disorder of thyroid, unspecified
Note: the following conditions are subtypes of each code from E10-14:
(E1x.0) Diabetic coma
(E1x.1) Diabetic ketoacidosis
(E1x.2) Diabetic nephropathy
(E1x.3) Diabetic retinopathy
(E1x.4) Diabetic neuropathy
(E1x.5) Diabetic angiopathy
(E1x.6) Diabetic arthropathy
(E10) Insulin-dependent diabetes mellitus
(E11) Non-insulin-dependent diabetes mellitus
(E12) Malnutrition-related diabetes mellitus
(E13) Other specified diabetes mellitus
(E14) Unspecified diabetes mellitus
(E15–E16) Other disorders of glucose regulation and pancreatic internal secretion
(E15) Nondiabetic hypoglycaemic coma
Drug-induced insulin coma in nondiabetic
Hyperinsulinism with hypoglycaemic coma
Hypoglycaemic coma NOS
(E16) Other disorders of pancreatic internal secretion
(E16.0) Drug-induced hypoglycaemia without coma
(E16.1) Other hypoglycaemia
Functional nonhyperinsulinaemic hypoglycaemia
Hyperinsulinism: NOS
Hyperinsulinism: functional
Hyperplasia of pancreatic islet beta cells NOS
Posthypoglycaemic coma encephalopathy
(E16.2) Hypoglycaemia, unspecified
(E16.3) Increased secretion of glucagon
(E16.4) Abnormal secretion of gastrin
Hypergastrinaemia
Zollinger-Ellison syndrome
(E16.8) Other specified disorders of pancreatic internal secretion
(E16.9) Disorder of pancreatic internal secretion, unspecified
(E20–E21) Parathyroid gland / PTH
(E20) Hypoparathyroidism
(E20.0) Idiopathic hypoparathyroidism
(E20.1) Pseudohypoparathyroidism
(E21) Hyperparathyroidism and other disorders of parathyroid gland
(E21.0) Primary hyperparathyroidism
(E21.1) Secondary hyperparathyroidism, not elsewhere classified
(E22–E23) Pituitary gland / ADH, oxytocin, GH, ACTH, TSH, LH, FSH, prolactin
(E22) Hyperfunction of pituitary gland
(E22.0) Acromegaly and pituitary gigantism
(E22.1) Hyperprolactinaemia
(E22.2) Syndrome of inappropriate secretion of antidiuretic hormone
Central precocious puberty
(E23) Hypofunction and other disorders of pituitary gland
(E23.0) Hypopituitarism
Fertile eunuch syndrome
Hypogonadotropic hypogonadism
Idiopathic growth hormone deficiency
Isolated deficiency of gonadotropin
Isolated deficiency of growth hormone
Isolated deficiency of pituitary hormone
Kallmann's syndrome
Lorain-Levi short stature
Necrosis of pituitary gland (postpartum)
Panhypopituitarism
Pituitary cachexia
Pituitary insufficiency NOS
Pituitary short stature
Sheehan's syndrome
Simmonds' disease
(E23.1) Drug-induced hypopituitarism
(E23.2) Diabetes insipidus
(E23.3) Hypothalamic dysfunction, not elsewhere classified
(E23.6) Other disorders of pituitary gland
Abscess of pituitary
Adiposogenital dystrophy
(E23.7) Disorder of pituitary gland, unspecified
(E24–E27) Adrenal gland / Aldosterone, cortisol, epinephrine, norepinephrine
(E24) Cushing's syndrome
(E24.0) Pituitary-dependent Cushing's disease
(E24.1) Nelson's syndrome
(E24.2) Ectopic ACTH syndrome
(E24.3) Alcohol-induced pseudo-Cushing's syndrome
(E24.4) Other Cushing's syndrome
(E24.5) Cushing's syndrome, unspecified
(E25) Adrenogenital disorders
(E25.0) Congenital adrenogenital disorders associated with enzyme deficiency
Congenital adrenal hyperplasia
Congenital adrenal hyperplasia due to 21-hydroxylase deficiency
(E26) Hyperaldosteronism
(E26.0) Primary hyperaldosteronism
Conn's syndrome
Primary aldosteronism due to adrenal hyperplasia (bilateral)
(E26.1) Secondary hyperaldosteronism
(E26.8) Other hyperaldosteronism
Bartter's syndrome
(E26.9) Hyperaldosteronism, unspecified
(E27) Other disorders of adrenal gland
(E27.0) Other adrenocortical overactivity
(E27.1) Primary adrenocortical insufficiency
Addison's disease
(E27.2) Addisonian crisis
(E27.3) Drug-induced adrenocortical insufficiency
(E27.4) Other and unspecified adrenocortical insufficiency
Hypoaldosteronism
Adrenocortical insufficiency NOS
(E27.5) Adrenomedullary hyperfunction
(E28–E30) Gonads / Estrogen, androgens, testosterone, etc.
(E28) Ovarian dysfunction
(E28.0) Estrogen excess
(E28.1) Androgen excess
(E28.2) Polycystic ovarian syndrome
(E28.3) Primary ovarian failure
Premature menopause NOS
(E29) Testicular dysfunction
(E29.0) Testicular hyperfunction
(E29.1) Testicular hypofunction
5-Alpha-reductase deficiency (with male pseudohermaphroditism)
Testicular hypogonadism NOS
(E30) Disorders of puberty, not elsewhere classified
(E30.0) Delayed puberty
(E30.1) Precocious puberty
(E30.8) Other disorders of puberty
Premature thelarche
(E31) Polyglandular dysfunction
(E31.0) Autoimmune polyglandular failure
Schmidt's syndrome
(E31.1) Polyglandular hyperfunction
(E32) Diseases of thymus
(E32.0) Persistent hyperplasia of thymus
Hypertrophy of thymus
(E32.1) Abscess of thymus
(E34) Other endocrine disorders
(E34.0) Carcinoid syndrome
(E34.1) Other hypersecretion of intestinal hormones
(E34.2) Ectopic hormone secretion, not elsewhere classified
(E34.3) Short stature, not elsewhere classified
NOS
constitutional
Laron-type
psychosocial
(E34.4) Constitutional tall stature
Constitutional gigantism
(E34.5) Androgen resistance syndrome
Reifenstein's syndrome
(E34.8) Other specified endocrine disorders
Progeria
(E35) Disorders of endocrine glands in diseases classified elsewhere
(E35.0) Disorders of thyroid gland in diseases classified elsewhere
(E35.1) Disorders of adrenal glands in diseases classified elsewhere
(E35.8) Disorders of other endocrine glands in diseases classified elsewhere
(E40) Kwashiorkor
(E41) Nutritional marasmus
(E42) Marasmic kwashiorkor
(E43) Unspecified severe protein-energy malnutrition
(E44) Protein-energy malnutrition of moderate and mild degree
(E45) Retarded development following protein-energy malnutrition
(E46) Unspecified protein-energy malnutrition
(E50) Vitamin A deficiency
(E50.0) Vitamin A deficiency with conjunctival xerosis
(E50.1) Vitamin A deficiency with Bitot's spot and conjunctival xerosis
(E50.2) Vitamin A deficiency with corneal xerosis
(E50.3) Vitamin A deficiency with corneal ulceration and xerosis
(E50.4) Vitamin A deficiency with keratomalacia
(E50.5) Vitamin A deficiency with night blindness
(E50.6) Vitamin A deficiency with xerophthalmic scars of cornea
(E50.7) Other ocular manifestations of vitamin A deficiency
Xerophthalmia NOS
(E51) Thiamine deficiency
(E51.1) Beriberi
(E51.2) Wernicke's encephalopathy
(E52) Niacin deficiency (pellagra)
(E53) Deficiency of other B group vitamins
(E53.0) Riboflavin deficiency
Ariboflavinosis
(E53.1) Pyridoxine deficiency
(E53.8) Deficiency of other specified B group vitamins
(E54) Ascorbic acid deficiency
Scurvy
(E55) Vitamin D deficiency
(E55.0) Rickets, active
(E56) Other vitamin deficiencies
(E56.0) Deficiency of vitamin E
(E56.1) Deficiency of vitamin K
(E58) Dietary calcium deficiency
(E59) Dietary selenium deficiency
(E60) Dietary zinc deficiency
(E61) Deficiency of other nutrient elements
(E61.1) Iron deficiency
(E61.2) Magnesium deficiency
(E61.3) Manganese deficiency
(E61.4) Chromium deficiency
(E61.5) Molybdenum deficiency
(E61.6) Vanadium deficiency
(E63) Other nutritional deficiencies
(E63.0) Essential fatty acid (EFA) deficiency
(E64) Sequelae of malnutrition and other nutritional deficiencies
(E65–E68) Obesity and other hyperalimentation
(E65) Localized adiposity
Fat pad
(E66) Obesity
(E66.0) Obesity due to excess calories
(E66.1) Drug-induced obesity
(E66.2) Extreme obesity with alveolar hypoventilation
Pickwickian syndrome
(E66.8) Other obesity
Morbid obesity
(E66.9) Obesity, unspecified
(E67) Other hyperalimentation
(E67.0) Hypervitaminosis A
(E67.1) Hypercarotenaemia
(E67.2) Megavitamin-B 6 syndrome
(E67.3) Hypervitaminosis D
(E68) Sequelae of hyperalimentation
(E70) Disorders of aromatic amino-acid metabolism
(E70.0) Classical phenylketonuria
(E70.1) Other hyperphenylalaninaemias
(E70.2) Disorders of tyrosine metabolism
Alkaptonuria (ILDS E70.210)
Ochronosis (ILDS E70.230)
Tyrosinaemia
(E70.3) Albinism
Oculocutaneous albinism (ILDS E70.310)
Partial albinism (ILDS E70.312)
Oculocutaneous albinism type 1 (tyrosinase-negative) (ILDS E70.314)
Oculocutaneous albinism type 2 (tyrosinase positive) (ILDS E70.314)
Albinoidism (ILDS E70.318)
Waardenburg syndrome (ILDS E70.320)
Chédiak–Higashi syndrome (ILDS E70.340)
Piebaldism (ILDS E70.350)
Tietz syndrome (ILDS E70.358)
Hermansky–Pudlak syndrome (ILDS E70.360)
Cross syndrome (ILDS E70.380)
(E70.8) Other disorders of aromatic amino-acid metabolism
Disorders of histidine metabolism
Disorders of tryptophan metabolism
(E70.9) Disorder of aromatic amino-acid metabolism, unspecified
(E71) Disorders of branched-chain amino-acid metabolism and fatty-acid metabolism
(E71.0) Maple-syrup-urine disease
(E71.1) Other disorders of branched-chain amino-acid metabolism
Propionic acidemia
Methylmalonic acidemia
Isovaleric acidemia
(E71.2) Disorder of branched-chain amino-acid metabolism, unspecified
(E71.3) Disorders of fatty-acid metabolism
Adrenoleukodystrophy (Addison-Schilder)
Muscle carnitine palmityltransferase deficiency
(E72) Other disorders of amino-acid metabolism
(E72.0) Disorders of amino-acid transport
Cystinuria
Cystinosis
Hartnup disease
Lowe's syndrome
(E72.1) Disorders of sulfur-bearing amino-acid metabolism
Cystathioninuria
Homocystinuria
Methioninaemia
Sulfite oxidase deficiency
(E72.2) Disorders of urea cycle metabolism
Argininaemia
Argininosuccinic aciduria
Citrullinaemia
Hyperammonaemia
(E72.3) Disorders of lysine and hydroxylysine metabolism
Glutaric aciduria
Hydroxylysinaemia
Hyperlysinaemia
Lysinuric protein intolerance
(E72.4) Disorders of ornithine metabolism
Ornithinaemia (types I, II)
(E72.5) Disorders of glycine metabolism
Hyperhydroxyprolinaemia
Hyperprolinaemia (types I, II)
Non-ketotic hyperglycinaemia
Sarcosinaemia
(E73) Lactose intolerance
(E74) Other disorders of carbohydrate metabolism
(E74.0) Glycogen storage disease
Glycogen storage disease type I (von Gierke's disease)
Glycogen storage disease type II (Pompe's disease)
Glycogen storage disease type III
Glycogen storage disease type IV
Glycogen storage disease type V (McArdle's disease)
(E74.1) Disorders of fructose metabolism
Essential fructosuria
Fructose-1,6-diphosphatase deficiency
Hereditary fructose intolerance
(E74.2) Disorders of galactose metabolism
Galactosaemia
Galactokinase deficiency
(E74.3) Other disorders of intestinal carbohydrate absorption
Glucose-galactose malabsorption
Sucrase deficiency
(E74.4) Disorders of pyruvate metabolism and gluconeogenesis
Deficiency of phosphoenolpyruvate carboxykinase
Deficiency of pyruvate carboxylase
Deficiency of pyruvate dehydrogenase
(E74.8) Other specified disorders of carbohydrate metabolism
Essential pentosuria
Oxalosis
Oxaluria
Renal glycosuria
(E74.9) Disorder of carbohydrate metabolism, unspecified
(E75) Disorders of sphingolipid metabolism and other lipid storage disorders
(E75.0) GM 2 gangliosidosis
Sandhoff disease
Tay-Sachs disease
(E75.1) Other gangliosidosis
GM 1
GM 3
Mucolipidosis IV
(E75.2) Other sphingolipidosis
Gaucher's disease (ILDS E75.220)
Niemann-Pick disease (ILDS E75.230)
Farber's disease (ILDS E75.240)
Fabry's disease (ILDS E75.250)
(E75.3) Sphingolipidosis, unspecified
(E75.4) Neuronal ceroid lipofuscinosis
Batten disease (Type 3)
Bielschowsky-Jansky disease (Type 2)
Kufs disease (Type 4)
Spielmeyer-Vogt disease (Type 3)
(E75.5) Other lipid storage disorders
Cerebrotendinous cholesterosis (van Bogaert-Scherer-Epstein)
Wolman's disease
(E75.6) Lipid storage disorder, unspecified
(E76) Disorders of glycosaminoglycan metabolism
(E76.0) Mucopolysaccharidosis, type I
Hurler syndrome
(E76.1) Mucopolysaccharidosis, type II
Hunter syndrome
(E76.2) Other mucopolysaccharidoses
Sanfilippo syndrome
Morquio syndrome
(E77) Disorders of glycoprotein metabolism
(E77.0) Defects in post-translational modification of lysosomal enzymes
Mucolipidosis II (I-cell disease)
Mucolipidosis III (pseudo-Hurler polydystrophy)
(E77.1) Defects in glycoprotein degradation
Aspartylglucosaminuria
Fucosidosis
Mannosidosis
Sialidosis (mucolipidosis I)
(E77.8) Other disorders of glycoprotein metabolism
(E77.9) Disorder of glycoprotein metabolism, unspecified
(E78) Disorders of lipoprotein metabolism and other lipidaemias
(E78.0) Pure hypercholesterolaemia
Familial hypercholesterolaemia
Fredrickson's hyperlipoproteinaemia, type IIa
Hyperbetalipoproteinaemia
Hyperlipidaemia, group A
Low-density-lipoprotein-type (LDL) hyperlipoproteinaemia
(E78.1) Pure hyperglyceridaemia
Endogenous hyperglyceridaemia
Fredrickson's hyperlipoproteinaemia, type IV
Hyperlipidaemia, group B
Hyperprebetalipoproteinaemia
Very-low-density-lipoprotein-type (VLDL) hyperlipoproteinaemia
(E78.2) Mixed hyperlipidaemia
Broad- or floating-betalipoproteinaemia
Fredrickson's hyperlipoproteinaemia, type IIb or III
Hyperbetalipoproteinaemia with prebetalipoproteinaemia
Hypercholesterolaemia with endogenous hyperglyceridaemia
Hyperlipidaemia, group C
Tubero-eruptive xanthoma
Xanthoma tuberosum
(E78.3) Hyperchylomicronaemia
Fredrickson's hyperlipoproteinaemia, type I or V
Hyperlipidaemia, group D
Mixed hyperglyceridaemia
(E78.4) Other hyperlipidaemia
Familial combined hyperlipidaemia
(E78.5) Hyperlipidaemia, unspecified
(E78.6) Lipoprotein deficiency
Abetalipoproteinaemia
High-density lipoprotein deficiency
Hypoalphalipoproteinaemia
Hypobetalipoproteinaemia (familial)
Lecithin cholesterol acyltransferase deficiency
Tangier disease
(E79) Disorders of purine and pyrimidine metabolism
(E79.0) Hyperuricaemia without signs of inflammatory arthritis and tophaceous disease
(E79.1) Lesch-Nyhan syndrome
(E79.8) Other disorders of purine and pyrimidine metabolism
Hereditary xanthinuria
(E80) Disorders of porphyrin and bilirubin metabolism
(E80.0) Hereditary erythropoietic porphyria
Erythropoietic protoporphyria (ILDS E80.010)
Erythropoietic porphyria, congenital (ILDS E80.020)
Gunther's disease (ILDS (ILDS E80.020)
Erythropoietic porphyria (ILDS (ILDS E80.030)
Erythropoietic coproporphyria (ILDS E80.040)
(E80.1) Porphyria cutanea tarda
Sporadic porphyria cutanea tarda (ILDS E80.110)
Familial porphyria cutanea tarda (ILDS E80.120)
(E80.2) Other porphyria
Acute intermittent porphyria (ILDS E80.210)
Hereditary coproporphyria (ILDS E80.222)
Variegate porphyria (ILDS E80.230)
Chester porphyria (ILDS E80.232)
Porphyria, hepatic (ILDS E80.240)
Pseudoporphyria (ILDS E80.250)
Toxic porphyria (ILDS E80.260)
Hepatoerythropoietic porphyria (ILDS E80.282)
Porphyria, NOS (ILDS E80.290)
(E80.3) Defects of catalase and peroxidase
Acatalasia (Takahara)
(E80.4) Gilbert's syndrome
(E80.5) Crigler-Najjar syndrome
(E80.6) Other disorders of bilirubin metabolism
Dubin-Johnson syndrome
Rotor's syndrome
(E80.7) Disorder of bilirubin metabolism, unspecified
(E83) Disorders of mineral metabolism
(E83.0) Disorders of copper metabolism
Wilson's disease
Menkes disease
(E83.1) Disorders of iron metabolism
Aceruloplasminemia
Hemochromatosis
(E83.2) Disorders of zinc metabolism
Acrodermatitis enteropathica
(E83.3) Disorders of phosphorus metabolism
Acid phosphatase deficiency
Familial hypophosphataemia
Hypophosphatasia
Vitamin-D-resistant osteomalacia
Vitamin-D-resistant rickets
(E83.4) Disorders of magnesium metabolism
Hypermagnesemia
Hypomagnesemia
(E83.5) Disorders of calcium metabolism
Familial hypocalciuric hypercalcaemia
Idiopathic hypercalciuria
(E84) Cystic fibrosis
(E85) Amyloidosis
(E85.0) Non-neuropathic heredofamilial amyloidosis
Familial Mediterranean fever
Hereditary amyloid nephropathy
(E85.1) Neuropathic heredofamilial amyloidosis
Amyloid polyneuropathy (Portuguese)
(E85.2) Heredofamilial amyloidosis, unspecified
(E85.3) Secondary systemic amyloidosis
Haemodialysis-associated amyloidosis
(E85.4) Organ-limited amyloidosis
Localized amyloidosis
(E85.8) Other amyloidosis
(E85.9) Amyloidosis, unspecified
(E86) Volume depletion
Dehydration
Hypovolaemia
(E87) Other disorders of fluid, electrolyte and acid-base balance
(E87.0) Hyperosmolality and hypernatraemia
(E87.1) Hypo-osmolality and hyponatraemia
(E87.2) Acidosis
Respiratory acidosis
Metabolic acidosis
Lactic acidosis
(E87.3) Alkalosis
(E87.4) Mixed disorder of acid-base balance
(E87.5) Hyperkalaemia
(E87.6) Hypokalaemia
(E87.7) Fluid overload
(E87.8) Other disorders of electrolyte and fluid balance, not elsewhere classified
Electrolyte imbalance NOS
Hyperchloraemia
Hypochloraemia
(E88) Other metabolic disorders
(E88.0) Disorders of plasma-protein metabolism, not elsewhere classified
Alpha-1-antitrypsin deficiency
Bisalbuminaemia
(E88.1) Lipodystrophy, not elsewhere classified
(E88.2) Lipomatosis, not elsewhere classified
(E88.8) Other specified metabolic disorders
Launois-Bensaude adenolipomatosis
Trimethylaminuria
(E88.9) Metabolic disorder, unspecified
(E89) Postprocedural endocrine and metabolic disorders, not elsewhere classified
(E89.0) Postprocedural hypothyroidism
(E89.1) Postprocedural hypoinsulinaemia
(E89.2) Postprocedural hypoparathyroidism
(E89.3) Postprocedural hypopituitarism
(E89.4) Postprocedural ovarian failure
(E89.5) Postprocedural testicular hypofunction
(E89.6) Postprocedural adrenocortical(-medullary) hypofunction
(E90) Nutritional and metabolic disorders in diseases classified elsewhere
Autoimmune disease (systemic) NOS (M35.9)
Certain conditions originating in the perinatal period (P00-P96)
Complications of pregnancy, childbirth and the puerperium (O00-O9A)
Congenital malformations, deformations and chromosomal abnormalities (Q00-Q99)
Endocrine, nutritional, and metabolic diseases (E00-E88)
Human immunodeficiency virus [HIV] disease (B20)
Injury, poisoning and certain other consequences of external causes (S00-T88)
Neoplasms (C00-D49)
Symptoms, signs, and abnormal clinical and laboratory findings, NEC (R00-R94)
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