Entrez 3385 | Ensembl ENSG00000076662 | |
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External IDs HomoloGene: 88479 GeneCards: ICAM3 | ||
Intercellular adhesion molecule 3 (ICAM3) also known as CD50 (Cluster of Differentiation 50), is a protein that in humans is encoded by the ICAM3 gene.
Contents
Function
The protein encoded by this gene is a member of the intercellular adhesion molecule (ICAM) family. All ICAM proteins are type I transmembrane glycoproteins, contain 2-9 immunoglobulin-like C2-type domains, and bind to the leukocyte adhesion LFA-1 protein. This protein is constitutively and abundantly expressed by all leukocytes and may be the most important ligand for LFA-1 in the initiation of the immune response. It functions not only as an adhesion molecule, but also as a potent signalling molecule.
Interactions
ICAM3 has been shown to interact with EZR and Moesin.
References
ICAM3 Wikipedia(Text) CC BY-SA