Supriya Ghosh (Editor)

Hypocretin (orexin) receptor 1

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Species
  
Human

Entrez
  
3061

Human
  
Mouse

Ensembl
  
ENSG00000121764

Hypocretin (orexin) receptor 1

Aliases
  
HCRTR1, OX1R, Hypocretin (orexin) receptor 1, hypocretin receptor 1

External IDs
  
MGI: 2385650 HomoloGene: 37492 GeneCards: HCRTR1

Orexin receptor type 1 (Ox1R or OX1), also known as hypocretin receptor type 1 (HcrtR1), is a protein that in humans is encoded by the HCRTR1 gene.

Contents

Function

The orexin 1 receptor (OX1), is a G-protein coupled receptor that is heavily expressed in projections from the lateral hypothalamus and is involved in the regulation of feeding behaviour. OX1 selectively binds the orexin-A neuropeptide. It shares 64% identity with OX2.

Agonists

  • Orexin-A

    • Antagonists

  • RTIOX-276 - Selective OX1 antagonist
  • ACT-335827 - Selective OX1 antagonist
  • Almorexant - Dual OX1 and OX2 antagonist
  • Lemborexant - Dual OX1 and OX2 antagonist
  • SB-334,867 - Selective OX1 antagonist
  • SB-408,124 - Selective OX1 antagonist
  • SB-649,868 - Dual OX1 and OX2 antagonist
  • Suvorexant - Dual OX1 and OX2 antagonist

    • References

    Hypocretin (orexin) receptor 1 Wikipedia
    (Text) CC BY-SA


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