Rahul Sharma (Editor)

Homoserine O succinyltransferase

Updated on
Edit
Like
Comment
Share on FacebookTweet on TwitterShare on LinkedInShare on Reddit
EC number
  
2.3.1.46

IntEnz
  
IntEnz view

ExPASy
  
NiceZyme view

CAS number
  
62213-51-8

BRENDA
  
BRENDA entry

KEGG
  
KEGG entry

In enzymology, a homoserine O-succinyltransferase (EC 2.3.1.46) is an enzyme that catalyzes the chemical reaction

succinyl-CoA + L-homoserine CoA + O-succinyl-L-homoserine

Thus, the two substrates of this enzyme are succinyl-CoA and L-homoserine, whereas its two products are CoA and O-succinyl-L-homoserine.

This enzyme belongs to the family of transferases, specifically those acyltransferases transferring groups other than aminoacyl groups. The systematic name of this enzyme class is succinyl-CoA:L-homoserine O-succinyltransferase. Other names in common use include homoserine O-transsuccinylase, and homoserine succinyltransferase. This enzyme participates in methionine metabolism and sulfur metabolism.

Structural studies

As of late 2016, three structures have been solved for this class of enzymes, with PDB accession codes 2GHR, 2H2W, and 2VDJ.

References

Homoserine O-succinyltransferase Wikipedia