Holmström or Holmstrom is a Swedish-language surname. Notable people with the surname include:
Agne Holmström (1893–1949), Swedish athlete who mainly competed in the 100 metres
August Wilhelm Holmström, Finnish and Russian silversmith and goldsmith
Axel Holmström (1881–1947), Swedish anarchist
Ben Holmstrom (born 1987), American professional ice hockey center
Bengt R. Holmström (born 1949), the Paul A. Samuelson Professor of Economics at M.I.T. and Nobel Prize winner
Bodil Holmström, Finnish orienteering competitor
Buzz Holmstrom (1909–1946), pioneer of running the Colorado River through the Grand Canyon
Carita Holmström (born 1954), Finnish pianist, singer and songwriter
John Holmstrom, American underground cartoonist and writer
Karl Holmström (1925–1974), Swedish ski jumper who competed in the 1950s
Kjell Holmström (1916–1999), Swedish bobsledder who competed in the 1950s and in the 1960s
Lakshmi Holmström, writer, literary critic and translator of Tamil fiction into English
Peter Holmström, American rock musician
Susanne Holmström (born 1947), Danish sociologist, best known for her writings on organizational legitimacy
Tomas Holmström (born 1973), Swedish professional ice hockey left winger