Holcomb is a surname, originating in a number of English villages with the name Holcombe. Early examples are recorded as de Holcombe, and the final e has been dropped from many family names, particularly in the USA. Notable people with the surname Holcomb include:
Al Holcomb, American Football coach
Amasa Holcomb, American farmer, surveyor, civil engineer, businessman, and manufacturer of surveying instruments
Benjamin Harrison Holcomb, American, one-time oldest living man
Bob Holcomb, American politician and attorney
Bobby Holcomb, American artist and musician
Charles Holcomb, retired Texan judge
Charlie Holcomb, former American -born English cricketer
Corey Holcomb, American stand-up comedian, radio host, and actor
David Holcomb, U.S. State Senator in the Ohio Senate
Doug Holcomb, professional basketball forward
Drew Holcomb, American singer and songwriter
Eric Holcomb, American politician
John Noble Holcomb, United States Army soldier
Kelly Holcomb, NFL quarterback
Marcus H. Holcomb, American politician and the 66th Governor of Connecticut
Mark Holcomb, American guitarist and songwriter of metal band, Periphery
Mike Holcomb, American Christian bass singer
Noah Holcomb, American mountain biker
Randy Holcomb, American professional basketball player
Richard Holcomb, commercial sex worker specialist, street outreach worker and HIV prevention counselor
Robin Holcomb, singer, songwriter and pianist
Rod Holcomb, American television director and producer
Roscoe Holcomb, American musician
Sarah Holcomb, former American actress
Silas A. Holcomb, Nebraska lawyer and politician
Steven Holcomb (born 1980), American bobsled driver
Stu Holcomb, college football coach
Thomas Holcomb, the seventeenth Commandant of the United States Marine Corps
William F. Holcomb, or Grizzly Bill, founder of Holcomb Valley, California