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Holýšov ( [ˈɦoliːʃof]; German: Holleischen) is a town in the Plzeň Region of the Czech Republic. It lies on the Radbuza River, some 20 km (12 mi) to the south-west from the region capital of Pilsen.
Holýšov is also the seat of the Municipality with Commissioned Local Authority within the Stod Municipality with Extended Competence.