Higginbotham is an English surname. Notable people with the surname include:
Abraham Higginbotham, American screenwriter
Andy Higginbotham, English footballer
Charles Higginbotham, Cricketer
Danny Higginbotham, English footballer
Don Higginbotham, Historian
Ernest Higginbotham, Footballer
Fred Higginbotham, Ice Hockey player
G. J. Higginbotham, American politician from Alabama
Grady Higginbotham, college coach of baseball, basketball, and football at Texas Tech
Harry Higginbotham, Australian footballer
Henry Higginbotham, Artist
Irene Higginbotham, songwriter and concert pianist
J. C. Higginbotham, jazz trombonist
James Higginbotham, Professor
Joan Higginbotham, astronaut
Kallum Higginbotham, Footballer
Irv Higginbotham, Baseball player
A. Leon Higginbotham, Jr., United States Appellate Court judge
Patrick Higginbotham, United States Appellate Court judge
Scott Higginbotham, Australian Rugby Union player
Susan Higginbotham, Author
Tegan Higginbotham, Australian actress and comedian