Higginbotham is an English surname. Notable people with the surname include:
Abraham Higginbotham, American screenwriterAndy Higginbotham, English footballerCharles Higginbotham, CricketerDanny Higginbotham, English footballerDon Higginbotham, HistorianErnest Higginbotham, FootballerFred Higginbotham, Ice Hockey playerG. J. Higginbotham, American politician from AlabamaGrady Higginbotham, college coach of baseball, basketball, and football at Texas TechHarry Higginbotham, Australian footballerHenry Higginbotham, ArtistIrene Higginbotham, songwriter and concert pianistJ. C. Higginbotham, jazz trombonistJames Higginbotham, ProfessorJoan Higginbotham, astronautKallum Higginbotham, FootballerIrv Higginbotham, Baseball playerA. Leon Higginbotham, Jr., United States Appellate Court judgePatrick Higginbotham, United States Appellate Court judgeScott Higginbotham, Australian Rugby Union playerSusan Higginbotham, AuthorTegan Higginbotham, Australian actress and comedian