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Helium Comedy Club is a stand-up comedy club chain in Center City Philadelphia, Pennsylvania, Buffalo, NY, Portland, Oregon, and St. Louis, Missouri. The club offers a three-act show which consists of an opener, feature and a headliner. Like many comedy clubs, the house has a 'two item minimum' for each audience member. Throughout the years many notable comics have been on the stage.
Comics include: Louis C.K., Bill Burr, Christopher Titus, Jay Pharoah, Damon Wayans, Adam Ferrara, Russ Meneve, Andy Kindler, Louis Ramey, Kevin Nealon, Patrice O'Neal, D. L. Hughley, Rich Vos, Gary Gulman, Jim Florentine, Norm Macdonald, Emo Philips and Mark Curry
Since 2006, Helium has sponsored an annual tournament called "Philly's Phunniest". The contest welcomes local comedians to compete against each other in timed sets which the audience (and judges) vote on.
The club also hosts a weekly open mic night that features around 20 local enthusiasts. Newcomers are given the chance to sign up for beginner sets ranging between 3-7 minutes.