Helicase–primase complex

A helicase–primase complex (also helicase-primase, Hel/Prim, H-P or H/P) is a complex of enzymes including DNA helicase and DNA primase. A helicase-primase associated factor protein may also be present.

Contents

• List of H P by virus name
• List of H P inhibitors
• References

The complex is used by herpesviruses in which it is responsible for lytic DNA virus replication. In many dsDNA viruses primase and helicase are fused into a single polypeptide, so that the primase and helicase domains correspond to the N-terminal and C-terminal parts of the protein, respectively. A helicase-primase inhibitor (HPI) is a drug that blocks this action through acting as an enzyme inhibitor.