Helfrich is both a surname and a given name. Notable people with the name include:
Surname:
Conrad Emil Lambert Helfrich (1886–1962), Royal Netherlands Navy admiral
John Helfrich (1795–1852), American pastor and homeopath
Mark Helfrich (disambiguation), multiple people
Theo Helfrich (1913–1978), German racing driver
Ty Helfrich (1890–1955), American baseball player
Wolfgang Helfrich (born 1932), German physicist
Oscar Louis Helfrich, Dutch official in Sumatra and Curacao
Given name:
Helfrich Bernhard Wenck (1739–1803), German historian and educator
Johann Helfrich von Müller (1746–1830), German engineer