Girish Mahajan (Editor)

Haplogroup NO

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Possible time of origin
  
over 45,000 years old

Ancestor
  
K2

Haplogroup NO

Possible place of origin
  
Southeast Asia or Southern China

Descendants
  
Primary descendant: NO1; secondary descendants: N and O.

Defining mutations
  
F549/M2335/S22380 (subclade NO1: M214/Page39)

Haplogroup NO (F549/M2335/S22380), also known as K2a is a human Y-chromosome DNA haplogroup.

Contents

The parent of Haplogroup NO is K2, itself a primary descendant of the broader Haplogroup K. NO is a phylogenetic sibling of the macrogroup K2b (the descendants of which include the major haplogroups M, P, Q, R and S). NO is also a sibling of the rare haplogroups K2c (P261), K2d (P402) and K2e (M147).

Its sole descendant subclade is Haplogroup NO1 (M214/Page39), which is the direct ancestor of Haplogroup N and Haplogroup O

Origins

Haplogroup NO (F549) is generally believed to have originated in East Asia. Haplogroups N and O are dominant within most populations of Northern and Eastern Eurasia.

Distribution

The only confirmed example of either NO* or NO1* is the remains of Ust'-Ishim man, dating from approximately 45,000 BP and found in Omsk Oblast, Russia. (Until 2016 these remains were erroneously classified as K2*.)

Due to subsequent advances in the definition of Haplogroup N (M231) and its subclades, other tentative cases of NO* or NO1* that have been suggested in research published between 2005 and 2011 – may instead belong to either N*, an unidentified subclade of N1, or the provisional subclade N2 (F3373/M2283/Page56/S323). These include:

  • 5.7% (2/35) of Bouyei males, in China or Vietnam;
  • a pool of four samples of Japanese males at 2.9% (6/210), particularly in Tokushima Prefecture at a rate of 5.7% (4/70), and;
  • small proportions of samples from Yizu, Malays, Mongolians, Daurs, Manchurian Evenks, Hezhes, Huis, Yaos, South Koreans, and Sô.
  • Likewise, cases previously regarded as possible examples of NO* or NO1*, and since ruled out, include:

  • two Han Chinese males previously found to be negative for M175 (i.e. Haplogroup O) and LLY22g (an obsolete, possibly inaccurate marker for N1), have subsequently have been found to belong to N* (N-M231), and;
  • a clade first identified in South India, defined by the SNP M147 and labelled "pre-NO", among other names, was found to be a sibling of NO (K2a) within Haplogroup K2 (K-M526); the new clade was renamed K2e.
  • Phylogenetic tree

    This phylogeny of Haplogroup NO is based on the ISOGG 2016 phylogeny and Karafet 2008 (which was based on the YCC 2008 phylogeny).

  • NO (F549/M2335/S22380) – also known as Haplogroup K2a
  • NO1 (M214/Page39) – no alternate designation, distinct from K2a, as of 2016
  • N (M231) – a.k.a. Haplogroup K2a1
  • O (M175/P186/P191/P196) – a.k.a. Haplogroup K2a2
  • References

    Haplogroup NO Wikipedia


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