PubChem CID 9794223 Formula C8H11NO5 Molar mass 201.176 g/mol | ChemSpider 7969990 3D model (Jmol) Interactive image | |
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HYDIA is a drug that is used in neuroscience research, which acts as a potent and selective antagonist for the group II metabotropic glutamate receptors (mGluR2/3). It has been useful in the mapping of the group II mGluR receptor proteins and their molecular modeling. HYDIA is similar in structure to group II mGluR agonists such as eglumegad and LY-404,039, but the addition of the 3-hydroxy group reverses the activity to a competitive antagonist. Other derivatives such as the 3-benzyloxy ether are more potent antagonists than HYDIA itself.
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HYDIA Wikipedia(Text) CC BY-SA