Supriya Ghosh

HOXD8

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Species  Human
Entrez  3234
Human  Mouse
Ensembl  ENSG00000175879
HOXD8
Aliases  HOXD8, HOX4, HOX4E, HOX5.4, homeobox D8
External IDs  MGI: 96209 HomoloGene: 10473 GeneCards: HOXD8

Homeobox protein Hox-D8 is a protein that in humans is encoded by the HOXD8 gene.

This gene belongs to the homeobox family of genes. The homeobox genes encode a highly conserved family of transcription factors that play an important role in morphogenesis in all multicellular organisms. Mammals possess four similar homeobox gene clusters, HOXA, HOXB, HOXC and HOXD, located on different chromosomes, consisting of 9 to 11 genes arranged in tandem. This gene is one of several homeobox HOXD genes located in a cluster on chromosome 2. Deletions that remove the entire HOXD gene cluster or the 5' end of this cluster have been associated with severe limb and genital abnormalities. In addition to effects during embryogenesis, this particular gene may also play a role in adult urogenital tract function.

References

HOXD8 Wikipedia


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