Harman Patil

HOXD10

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Species  Human
Entrez  3236
Human  Mouse
Ensembl  ENSG00000128710
HOXD10
Aliases  HOXD10, HOX4, HOX4D, HOX4E, Hox-4.4, homeobox D10
External IDs  MGI: 96202 HomoloGene: 1619 GeneCards: HOXD10

Homeobox D10, also known as HOXD10, is a protein which in humans is encoded by the HOXD10 gene.

Contents

Function

This gene is a member of the Abd-B homeobox family and encodes a protein with a homeobox DNA-binding domain. It is included in a cluster of homeobox D genes located on chromosome 2. The encoded nuclear protein functions as a sequence-specific transcription factor that is expressed in the developing limb buds and is involved in differentiation and limb development.

Clinical significance

Mutations in this gene have been associated with Wilms' tumor and congenital vertical talus (also known as "rocker-bottom foot" deformity or congenital convex pes valgus) and/or a foot deformity resembling that seen in Charcot-Marie-Tooth disease.

Regulation

The HOXD10 gene is repressed by the microRNAs miR-10a and miR-10b.

References

HOXD10 Wikipedia


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