Trisha Shetty (Editor)

HMG box

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Covid-19
Symbol  PF00505
InterPro  IPR009071
SUPERFAMILY  1hsm
Pfam  PF00505
SCOP  1hsm
Pfam  structures
HMG-box

In molecular biology, the HMG-box (high mobility group box) is a protein domain which is involved in DNA binding.

Contents

Structure

The structure of the HMG-box domain contains three alpha helices separated by loops (see figure to the right).

Function

HMG-box containing proteins only bind non-B-type DNA conformations (kinked or unwound) with high affinity. HMG-box domains are found in high mobility group proteins, which are involved in the regulation of DNA-dependent processes such as transcription, replication, and DNA repair, all of which require changing the conformation of chromatin. The single and the double box HMG proteins alter DNA architecture by inducing bends upon binding.

References

HMG-box Wikipedia


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