Samiksha Jaiswal (Editor)

HLA C

Updated on
Edit
Like
Comment
Share on FacebookTweet on TwitterShare on LinkedInShare on Reddit
Species
  
Human

Entrez
  
3107

Human
  
Mouse

Ensembl
  
n/a

HLA-C

Aliases
  
HLA-C, D6S204, HLA-JY3, HLC-C, PSORS1, major histocompatibility complex, class I, C, MHC

External IDs
  
OMIM: 142840 HomoloGene: 133080 GeneCards: HLA-C

HLA-C belongs to the MHC (human = HLA) class I heavy chain receptors. The C receptor is a heterodimer consisting of a HLA-C mature gene product and β2-microglobulin. The mature C chain is anchored in the membrane. MHC Class I molecules, like HLA-C, are expressed in nearly all cells, and present small peptides to the immune system which surveys for non-self peptides.

Contents

HLA-C is a locus on chromosome 6, which encodes for a large number of HLA-C alleles that are Class-I MHC receptors. HLA-C, localized proximal to the HLA-B locus, is located on the distal end of the HLA region. Most HLA C:B haplotypes are in strong linkage disequilibrium and many are as ancient as the human species itself.

By serotype

Cw1: Multinodular goiters

By allele

C*16: B chronic lymphocytic leukemia

Nomenclature

C*01

  • Cw1 Serotype: C*01:02 and C*01:09
  • Cw11 ?
  • C*01:04 to *01:08


    • C*02

  • Cw2 Serotype: C*02:02 and *02:08
  • C*02:03 to *02:07, and 02:09


    • C*03

  • Cw9 Serotype: C*03:03
  • Cw10 Serotype: C*03:02, *03:04, and *03:06
  • Cw3 Serotype: C*03:07
  • C*03:05 and 03:08


    • C*04

  • Cw4 Serotype: C*0401, *0407, and *0410


    • C*05

  • Cw5 Serotype: C*05:01 and *05:02
  • C*05:03 to *05:06 and *05:08 to *05:10


    • C*06

  • Cw6 Serotype: C*06:02 and *06:05
  • C*06:03, *06:04 and *06:06 to *06:11
  • Cw7 Serotype: C*07:01 to *07:06, *07:12, *07:14, *07:16
  • C*07:07 to *07:11, *07:13, *07:15, and *07:17 to *07:29


    • C*08

  • Cw8 Serotype: C*08:01, *08:02 and *08:03
  • C*08:05 to *08:12


    • C*12:02 to *12:15

    C*14:02 to *14:05

    C*15:01 to *15:11

    C*16:01 to *16:06

    C*17:01 to *17:03

    C*18:01 and *18:02

    Common Haplotype

    Cw4-B35 (Western Africa to Native Americans) Cw7-B7 (Western Eurasia, South Africa) Cw7-B8 (Western Eurasia) Cw1-B46 (China, Indochina) Cw5-B44 (Western Eurasia)

    Interactions

    HLA-C has been shown to interact with:

  • KIR2DL1, with various members of the
  • LILRA3 and
  • Leukocyte immunoglobulin-like receptor family, particularly the activating receptors LILRA1 and

    • References

    HLA-C Wikipedia
    (Text) CC BY-SA


    Similar Topics