Supriya Ghosh (Editor)

HLA A74

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Covid-19
Structure  αβ heterodimer
allele  Available structures
Subtype  allele
A74  *7401
HLA-A74
Protein  transmembrane receptor/ligand
Subunits  HLA-A*74--, β2-microglobulin

HLA-A74 (A74) is a human leukocyte antigen serotype within HLA-A serotype group. The serotype is determined by the antibody recognition of α74 subset of HLA-A α-chains. For A74, the alpha "A" chain are encoded by the HLA-A*74 allele group and the β-chain are encoded by B2M locus. A74 and A*74 are almost synonymous in meaning. A74 is a split antigen of the broad antigen serotype A19. A74 is a sister serotype of A29, A30, A31, A32, and A33.

Contents

A74 is more common in Subsaharan Africa. A74 is a rare HLA-A allele group.

Serotype

A74 has a poor serotyping rate.

Disease associations

A significant association has been found between A74 and nasal polyposis.

References

HLA-A74 Wikipedia


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