Entrez 348980 | Ensembl ENSG00000164588 | |
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Aliases HCN1, BCNG-1, BCNG1, EIEE24, HAC-2, hyperpolarization activated cyclic nucleotide gated potassium channel 1 External IDs MGI: 1096392 HomoloGene: 32093 GeneCards: HCN1 | ||
Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1 is a protein that in humans is encoded by the HCN1 gene.
Contents
Function
Hyperpolarization-activated cation channels of the HCN gene family, such as HCN1, contribute to spontaneous rhythmic activity in both heart and brain.
Tissue distribution
HCN1 channel expression is found in the sinoatrial node, the neocortex, hippocampus, cerebellar cortex, dorsal root ganglion, trigeminal ganglion and brainstem.
Interactions
HCN1 has been shown to interact with HCN2.
Epilepsy
De novo mutations in HCN1 cause epilepsy .
References
HCN1 Wikipedia(Text) CC BY-SA