Species Human Entrez 3048 | Human Mouse Ensembl ENSG00000196565 | |
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Aliases HBG2, HBG-T1, TNCY, hemoglobin subunit gamma 2 External IDs MGI: 96027 HomoloGene: 128032 GeneCards: HBG2 | ||
Hemoglobin subunit gamma-2 is a protein that in humans is encoded by the HBG2 gene.
Function
The gamma globin genes (HBG1 and HBG2, this gene) are normally expressed in the fetal liver, spleen and bone marrow. Two gamma chains together with two alpha chains constitute fetal hemoglobin (HbF) which is normally replaced by adult hemoglobin (HbA) at birth. In some beta-thalassemias and related conditions, gamma chain production continues into adulthood. The two types of gamma chains differ at residue 136 where glycine is found in the G-gamma product (HBG2) and alanine is found in the A-gamma product (HBG1). The former is predominant at birth. The order of the genes in the beta-globin cluster is: 5' - epsilon – gamma-G – gamma-A – delta – beta - 3'.
References
HBG2 Wikipedia(Text) CC BY-SA