Species Human Entrez 3035 | Human Mouse Ensembl ENSG00000170445 | |
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Aliases HARS, HRS, USH3B, CMT2W, histidyl-tRNA synthetase External IDs MGI: 108087 HomoloGene: 1592 GeneCards: HARS | ||
Histidyl-tRNA synthetase (HARS) also known as histidine-tRNA ligase, is an enzyme which in humans is encoded by the HARS gene.
Contents
Function
Aminoacyl-tRNA synthetases are a class of enzymes that charge tRNAs with their cognate amino acids. The protein encoded by this gene is a cytoplasmic enzyme which belongs to the class II family of aminoacyl tRNA synthetases. The enzyme is responsible for the synthesis of histidyl-transfer RNA, which is essential for the incorporation of histidine into proteins. The gene is located in a head-to-head orientation with HARSL on chromosome five, where the homologous genes share a bidirectional promoter.
Clinical significance
The gene product is a frequent target of autoantibodies in the human autoimmune disease polymyositis/dermatomyositis.
Interactions
HARS has been shown to interact with EEF1B2 and EEF1G.