H6 tells the story of Antonio Frau, a serial killer set free after serving 25 years in jail for the violent murder of his girlfriend. After inheriting an old motel from a relative he never knew, he sees this as a signal and takes to his holy task of relieving the grief of those who have lost the will to live. He takes his victims to room Number 6 in the motel where he 'purifies' them, while, at the same time, continues his everyday life next to his wife. A mistake leads to his arrest, and his plan to become rich and famous takes relevance.
The film premiered on 29 April 2005 as part of the Málaga Film Festival. It was on 3 November 2005 part of the San Sebastián Horror and Fantasy Film Festival and the renomated Festival de Cine Negro de Manresa on 19 November 2005. H6 had a theatrical release in Spain on 7 July 2006 and was in the United States released as direct to video production on 21 November 2006.