Guyer is a surname. Notable people with the surname include:
Brandon Guyer (born 1986), American professional baseball outfielder
Cindy Guyer, American model and actress
Denis Guyer (born 1966), American politician
Gino Guyer (born 1983), American professional ice hockey centre
Gordon Guyer (born 1926), president of Michigan State University from 1992 to 1993
Jane I. Guyer, George Armstrong Kelly Professor in the Department of Anthropology at The Johns Hopkins University
Lux Guyer (1894–1955), Swiss architect
Paul Guyer, Jonathan Nelson Professor of Philosophy at Brown University
Reyn Guyer (born 1935), American inventor
Tennyson Guyer (1913–1981), member of the United States House of Representatives
Thad McIntosh Guyer (born 1950), American civil rights lawyer
U. S. Guyer (1868–1943), U.S. Representative from Kansas
