Guyer is a surname. Notable people with the surname include:
Brandon Guyer (born 1986), American professional baseball outfielderCindy Guyer, American model and actressDenis Guyer (born 1966), American politicianGino Guyer (born 1983), American professional ice hockey centreGordon Guyer (born 1926), president of Michigan State University from 1992 to 1993Jane I. Guyer, George Armstrong Kelly Professor in the Department of Anthropology at The Johns Hopkins UniversityLux Guyer (1894–1955), Swiss architectPaul Guyer, Jonathan Nelson Professor of Philosophy at Brown UniversityReyn Guyer (born 1935), American inventorTennyson Guyer (1913–1981), member of the United States House of RepresentativesThad McIntosh Guyer (born 1950), American civil rights lawyerU. S. Guyer (1868–1943), U.S. Representative from Kansas