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There have been two baronetcies created for the Guise family, one in the Baronetage of England and one in the Baronetage of Great Britain. The latter creation is extant as of 2014.
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The Guise Baronetcy, of Elmore in the County of Gloucester, was created in the Baronetage of England on 10 July 1661 for Christopher Guise, Member of Parliament for Gloucestershire. The second Baronet also sat as Member of Parliament for Gloucestershire. The third represented Gloucestershire and Great Marlow in the House of Commons. The fourth Baronet was Member of Parliament for Aylesbury. The fifth Baronet represented Gloucestershire in Parliament. This title became extinct on his death in 1783.
The Guise Baronetcy, of Highnam Court in the County of Gloucester, was created in the Baronetage of Great Britain on 9 December 1783 for John Guise. The cousin and heir male of the last Baronet of the 1661 creation, he was the great-grandson of Henry Guise, younger brother of the first baronet. The second Baronet sat as MP for Gloucestershire and Gloucestershire East. The fourth and fifth Baronets both served as High Sheriff of Gloucestershire.
The family surname is pronounced "Ghize" and their family seat is Elmore Court, located in Elmore, near Gloucester.