Symbol GUCA2A Entrez 2980 OMIM 139392 | Alt. symbols GUCA2 HUGO 4682 PDB 1O8R | |
 | ||
Guanylin is a 15 amino acid polypeptide that is secreted by goblet cells in the colon. Guanylin acts as an agonist of the guanylyl cyclase receptor GC-C and regulates electrolyte and water transport in intestinal and renal epithelia. Upon receptor binding, guanylin increases the intracellular concentration of cGMP, induces chloride secretion and decreases intestinal fluid absorption, ultimately causing diarrhoea. The peptide stimulates the enzyme through the same receptor binding region as the heat-stable enterotoxins.
Contents
Human proteins containing this domain
GUCA2A; GUCA2B;
Structure
This peptide has two topogies, both isoforms are shown below:
References
Guanylin Wikipedia(Text) CC BY-SA