Guanosine diphosphatase

In enzymology, a guanosine-diphosphatase (EC 3.6.1.42) is an enzyme that catalyzes the chemical reaction

Thus, the two substrates of this enzyme are GDP and H₂O, whereas its two products are GMP and phosphate.

This enzyme belongs to the family of hydrolases, specifically those acting on acid anhydrides in phosphorus-containing anhydrides. The systematic name of this enzyme class is GDP phosphohydrolase. This enzyme is also called GDPase.