Entrez 2692 | Ensembl ENSG00000106128 | |
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External IDs OMIM: 139191 MGI: 95710 HomoloGene: 640 GeneCards: GHRHR | ||
The growth-hormone-releasing hormone receptor (GHRHR) is a G-protein-coupled receptor that binds growth hormone-releasing hormone. The GHRHR activates a Gs protein that causes a cascade of cAMP via Adenylate cyclase.
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Function
This gene, expressed in the pituitary, encodes a receptor for growth-hormone-releasing hormone. Binding of this hormone to the receptor leads to synthesis and release of growth hormone. Mutations in this gene have been associated with isolated growth-hormone deficiency (IGHD), also known as Dwarfism of Sindh, a disorder characterized by short stature. Many alternate transcriptional splice variants encoding different isoforms have been described, but only two have been characterized to date.
Agonists
Antagonists
References
Growth-hormone-releasing hormone receptor Wikipedia(Text) CC BY-SA