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Grosthuizen is a hamlet in the Dutch province of North Holland. It is a part of the municipality of Koggenland, and lies about 7 km southwest of Hoorn.
Grosthuizen was a separate municipality between 1817 and 1854, when it was merged with Avenhorn.
The statistical area "Grosthuizen", which also can include the surrounding countryside, has a population of around 410.