Grillo is an Italian surname. Notable people with the surname include:
Angelo Grillo, Italian poet and lyricist who wrote madrigals for Claudio MonteverdiAntonio Grillo (footballer, born 1986), Italian football defenderAntonio Grillo (footballer, born 1991), Italian football defenderBeppe Grillo, Italian comedian and politicianCasey Grillo, American drummerChuck Grillo, former American professional ice hockey executiveEdward Grillo, American mobsterElisabetta and Francesca Grillo, defendants in R v Grillo and GrilloEmiliano Grillo, Argentine professional golferErnesto Grillo, Argentine football playerFrank Grillo, American actorFrancesco Grillo, Italian political economy scientist, journalist and managerFriedrich Grillo, German industrialistGabriela Grillo, German equestrian and businesswomanGiovanni Grillo, leader of a revolt in Sorrento against the Spanish in the 17th centuryJanet Grillo, American filmmaker and screenwriterLeo Grillo, American film actor, producer and animal welfare activistManuela Grillo, former Italian sprinterMike (Grell) Grillo, American comic book artist and writerNatasha Grillo, Italian professional racing cyclistNiccolò Grillo, Italian composerOdhise Grillo, Albanian writer of children's booksParide Grillo (born 1982), Italian cyclistRoger Grillo, former American ice hockey player and coachSantiago Grillo, Colombian windsurferTyran Grillo, writer and translatorFictional characters:
Jack Grillo, video game character