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The goblet cell carcinoid, abbreviated GCC and also known as crypt cell carcinoma and neuroendocrine tumour with goblet cell differentiation, is a rare biphasic gastrointestinal tract tumour that consists of a neuroendocrine component and a conventional carcinoma, histologically arising from Paneth cells.
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Sign and symptoms
GCCs may present as appendicitis.
Diagnosis
GCCs are diagnosed by pathology. They have a characteristic biphasic appearance which includes (1) goblet cell-like cells, and (2) neuroendocrine-type nuclear chromatin (stippled chromatin).
Prognosis
GCCs have an aggressive course compared to other appendiceal neuroendocrine tumours.
Treatment
GCCs are treated with surgery.
References
Goblet cell carcinoid Wikipedia(Text) CC BY-SA