Suvarna Garge (Editor)

Glyoxylate reductase (NADP )

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EC number  1.1.1.79
IntEnz  IntEnz view
ExPASy  NiceZyme view
CAS number  37250-17-2
BRENDA  BRENDA entry
KEGG  KEGG entry

In enzymology, a glyoxylate reductase (NADP+) (EC 1.1.1.79) is an enzyme that catalyzes the chemical reaction

glycolate + NADP+ glyoxylate + NADPH + H+

Thus, the two substrates of this enzyme are glycolate and NADP+, whereas its 3 products are glyoxylate, NADPH, and H+.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-OH group of donor with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is glycolate:NADP+ oxidoreductase. Other names in common use include NADPH-glyoxylate reductase, and glyoxylate reductase (NADP+). This enzyme participates in pyruvate metabolism and glyoxylate and dicarboxylate metabolism.

Structural studies

As of late 2007, 3 structures have been solved for this class of enzymes, with PDB accession codes 2GCG, 2H1S, and 2Q50.

References

Glyoxylate reductase (NADP+) Wikipedia


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