Species Human Entrez 2741 | Human Mouse Ensembl ENSG00000145888 | |
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Aliases GLRA1, HKPX1, STHE, Glycine receptor, alpha 1, glycine receptor alpha 1 External IDs MGI: 95747 HomoloGene: 20083 GeneCards: GLRA1 | ||
Glycine receptor subunit alpha-1 is a protein that in humans is encoded by the GLRA1 gene.
Contents
Function
The inhibitory glycine receptor mediates postsynaptic inhibition in the spinal cord and other regions of the central nervous system. It is a pentameric receptor composed of alpha and beta subunits. The GLRB gene encodes the beta subunit of the receptor.
Clinical signficance
Mutations in the gene have been associated with hyperekplexia, a neurologic syndrome associated with an exaggerated startle reaction.
References
Glycine receptor, alpha 1 Wikipedia(Text) CC BY-SA