Glycine dehydrogenase (cytochrome)

In enzymology, a glycine dehydrogenase (cytochrome) (EC 1.4.2.1) is an enzyme that catalyzes the chemical reaction

glycine + H₂O + 2 ferricytochrome c ⇌ glyoxylate + NH₃ + 2 ferrocytochrome c + 2 H⁺

The 3 substrates of this enzyme are glycine, H₂O, and ferricytochrome c, whereas its 4 products are glyoxylate, NH₃, ferrocytochrome c, and H⁺.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-NH2 group of donors with a cytochrome as acceptor. The systematic name of this enzyme class is glycine:ferricytochrome-c oxidoreductase (deaminating). This enzyme is also called glycine---cytochrome c reductase. This enzyme participates in glycine, serine and threonine metabolism.